![]() “Rotational-Echo Double-Resonance NMR Distance Measurements for the Tubulin-Bound Paclitaxel Conformation.” J. Kingston “Modern Natural Products Drug Discovery and its Relevance to Biodiversity Conservation” J. Kingston, Antiproliferative and antiplasmodial dimeric phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest. Callmander, Etienne Rakotobe, Richard Randrianaivo, Vincent E. Isolation of Antiplasmodial Anthraquinones from Kniphofia ensifolia, and Synthesis and Structure-activity Relationships of Related Compounds. Da Fonseca, Isabel Osorio Brodie, Peggy J. PMCID: PMC4139185.ĭai, Yumin Harinantenaina, Liva Bowman, Jessica D. The Quest for a Simple Bioactive Analog of Paclitaxel as a Potential Anticancer Agent. This project blends synthesis and biological studies to improve on one of the most important new anti-cancer natural products of the past 30 years. Preliminary results are encouraging, and one of the agents we have helped develop is approximately twentyfold more potent than paclitaxel itself. to develop a gold nanoparticle approach to drug delivery. It does have some significant side-effects, and we are working with CytImmune Sciences Inc. The complex diterpenoid natural product taxol is an exciting anti-cancer drug that is currently in clinical use against ovarian and breast cancer. in this work, and any compounds with significant anticancer activity will be offered to Eisai for development.Ĭhemistry and Drug Delivery of Paclitaxel Alexandria is located 30 minutes south of Washington, D.C., and serves patients from Virginia, Maryland and Washington, D.C. The equipment used in this program is not suitable for small children. The new bioactive compounds below have all been isolated from plants collected in this program. Center for Discovery Alexandria is an eating disorder treatment center that opened in 2016 and accepts patients of all genders ages 10-18. Learn the essentials of basic target archery, a skill that, thanks to artifacts found at the park, we know humans have been practicing here for thousands of years. Any royalties from the resulting drugs will be shared with Madagascar as an economic incentive to maintain their tropical forests. We have also helped to set up a malaria screening facility in Madagascar, and we are working to isolate antimalarial compounds in collaboration with our Malagasy colleagues. Plants, marine organisms, and microbial species are collected in Madagascar and screened for bioactivity at Virginia Tech, and those with anticancer activity or CNS activity are studied in our laboratories. We have joined with conservation, industrial, and botanical groups to develop a model program for drug discovery and biodiversity conservation in Madagascar. Regrettably these forests are disappearing at a rapid rate as they are logged for timber or conversion to agricultural purposes. Natural products have provided over a third of currently used pharmaceuticals, and the tropical rain forests of the world represent a great and largely untapped source of new natural products examples of some of the compounds isolated in the Kingston group are shown below. Drug Discovery and Biodiversity Conservation in Madagascar
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